ʻO Terlipressin Acetate no ke koko ʻokoʻa o ka esophageal
Huahana Huahana
| Inoa | N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin |
| Helu CAS | 14636-12-5 |
| ʻAno molekala | C52H74N16O15S2 |
| Kaumaha molekula | 1227.37 |
| Helu EINECS | 238-680-8 |
| Lae paila | 1824.0±65.0 °C (Wānana ʻia) |
| ʻO ka mānoanoa | 1.46±0.1 g/cm3(Wanamua) |
| Nā kūlana mālama | E mālama i kahi pōʻeleʻele, ea inert, E mālama i loko o ka pahu hau, ma lalo o -15°C. |
| ʻAkika helu | (pKa) 9.90±0.15 (Wanamua) |
Nā huaʻōlelo like
[N-α-Triglycyl-8-lysine]-vasopressin;130:PN: WO2010033207SEQID:171claiMedprotein;1-Triglycyl-8-lysineVasopressin;Nα-Glycyl-glycyl-glycyl-[8-lysine]-vasopressin;Nα-Glycyl-glycyl-glycyl-lysine-vasopressin;Nα-Glycylglycylglycyl-vasopressin;Nα-Gly-Gly-Gly-8-Lys-vasopressin;ʻO Terlipressin, Terlipressine, Terlipressina, Terlipressinum.
wehewehe
ʻO Terlipressin, nona ka inoa kemika he triglycyllysine vasopressin, he hoʻomākaukau vasopressin lōʻihi synthetic hou.He ʻano prodrug ia, ʻaʻole hoʻoikaika wale.Hana ʻia e aminopeptidase in vivo e "hoʻokuʻu" mālie i ka lysine vasopressin ikaika ma hope o ka wehe ʻana i nā koena glycyl ʻekolu ma kāna N-terminus.No laila, hana ʻo terlipressin ma ke ʻano he reservoir e hoʻokuʻu i ka lysine vasopressin ma kahi wikiwiki paʻa.
ʻO ka hopena pharmacological o terlipressin ka hana ʻana i ka splanchnic vascular smooth muscle a hōʻemi i ke kahe o ke koko splanchnic (e like me ka hōʻemi ʻana i ke kahe o ke koko i loko o ka mesentery, spleen, kōpū, a me nā mea ʻē aʻe), a laila e hōʻemi i ke kahe koko portal a me ke kaomi puka.Ma ka ʻaoʻao ʻē aʻe, hiki iā ia ke hōʻemi i ka plasma ʻO ka hopena o ka manaʻo o ka renin, ma laila e hoʻonui ai i ke kahe koko renal, hoʻomaikaʻi i ka hana renal a me ka hoʻonui ʻana i ka urine i nā maʻi me ka maʻi hepatorenal.ʻO Terlipressin wale nō ka lāʻau lapaʻau i hiki ke hoʻomaikaʻi i ke ola o nā maʻi me ka esophageal variceal hemorrhage.Ua hoʻohana nui ʻia i ka lāʻau lapaʻau o ka hemorrhage variceal.Eia kekahi, ua hoʻohana maikaʻi ʻia ka terlipressin i loko o ke ake a me nā puʻupaʻa.Ma keʻano laulā, hiki ke pāʻani i kahi hana maikaʻi i ka noho pū ʻana i ka haʻalulu refractory a me ka hoʻōla ʻana o ka cardiopulmonary.Ke hoʻohālikelikeʻia me ka vasopressin, he hopena lōʻihi kona,ʻaʻole ia e hoʻopilikia i nā pilikia, e like me ka fibrinolysis a me nā pilikia koʻikoʻi i ka'ōnaehana cardiovascular, a maʻalahi ka hoʻohana (intravenous injection), iʻoi aku ka maikaʻi no ka mālama koʻikoʻi a koʻikoʻi.Hoʻopakele a mālama ʻana i nā maʻi maʻi koʻikoʻi.
