Hoʻoponopono ʻo Leuprorelin Acetate i ka huna ʻana o nā Hormones Gonadal
Huahana Huahana
| Inoa | Leuprorelin |
| Helu CAS | 53714-56-0 |
| ʻAno molekala | C59H84N16O12 |
| Kaumaha molekula | 1209.4 |
| Helu EINECS | 633-395-9 |
| Kahuli kiko'ī | D25 -31.7° (c = 1 i ka 1% acetic acid) |
| ʻO ka mānoanoa | 1.44±0.1 g/cm3 (Wānana ʻia) |
| Kūlana mālama | -15°C |
| Puka | Maʻemaʻe |
| ʻAkika helu | (pKa) 9.82±0.15 (Wanamua) |
| Ka hoʻoheheʻe wai | Hiki ke hoʻoheheʻe ʻia i ka wai ma 1mg/ml |
Nā huaʻōlelo like
LH-RHLEUPROLIDE;LEUPROLIDE;LEUPROLIDE(KANAKA);LEUPRORELIN;[DES-GLY10,D-LEU6,PRO-NHET9]-LUTEINIZINGHORMONE-RELEASINGHORMONEHUMAN;(DES-GLY10,D-LEU6,PRO-NHETRINGA;LUMHORONESINGHORMONEHUMAN; DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZINGHORMONE-RELEASINGFACTOR;[DES-GLY10,D-LEU6,PRO-NHET9]-LH-RH(KANAKA)
Ka hopena lāʻau lapaʻau
ʻO Leuprolide, goserelin, triprelin, a me nafarelin kekahi mau lāʻau lapaʻau i hoʻohana mau ʻia i ka hana lapaʻau e wehe i nā ovaries no ka mālama ʻana i ka maʻi maʻi umauma premenopausal a me ka maʻi maʻi prostate.(i kapa ʻia ʻo GnRH-a mau lāʻau lapaʻau), GnRH-a nā lāʻau lapaʻau i like ke ʻano me GnRH a hoʻokūkū pū me nā mea loaʻa GnRH pituitary.ʻO ia hoʻi, ke emi nei ka gonadotropin huna ʻia e ka pituitary, kahi e alakaʻi ai i ka emi nui o ka hormone sex i huna ʻia e ka ovary.
ʻO ka Leuprolide he hormone hoʻokuʻu gonadotropin (GnRH) analog, he peptide i haku ʻia me 9 amino acids.Hiki i kēia huahana ke pale pono i ka hana o ka pituitary-gonadal system, ke kū'ē i nā enzymes proteolytic a me ka pili i ka pituitary GnRH receptor i ʻoi aku ka ikaika ma mua o GnRH, a ʻo ka hana o ka hoʻolaha ʻana i ka hoʻokuʻu ʻana o ka luteinizing hormone (LH) ma kahi o 20 mau manawa. o GnRH.ʻOi aku ka ikaika o ka hopena i ka hana pituitary-gonad ma mua o GnRH.I ka wā mua o ka mālama ʻana, hiki ke hoʻonui ʻia ka follicle stimulating hormone (FSH), LH, estrogen a i ʻole androgen, a laila, ma muli o ka emi ʻana o ka pane o ka pituitary gland, ua kāohi ʻia ka huna ʻana o FSH, LH a me ka estrogen a i ʻole androgen. ka hopena i ka hilinaʻi ʻana i nā hormones sex.ʻO nā maʻi moe (e like me ka maʻi prostate, endometriosis, etc.) he hopena lapaʻau.
I kēia manawa, hoʻohana nui ʻia ka paʻakai acetate o ka leuprolide i ka maʻi maʻi, no ka mea, ʻoi aku ka paʻa o ka hana o ka leuprolide acetate i ka mahana o ka lumi.Pono e hoʻolei ʻia ka wai.Hiki ke hoʻohana ʻia no ka mālama ʻana i ka lāʻau lapaʻau o ka endometriosis a me ka fibroids uterine, ka wā ʻōpio precocious, ka maʻi maʻi premenopausal a me ka maʻi prostate, a no ka hoʻokahe koko ʻana o ka ʻōpū i contraindicated a ʻaʻole pono no ka lāʻau hormone maʻamau.Hiki ke hoʻohana ʻia ma ke ʻano he lāʻau lapaʻau ma mua o ka wehe ʻana o ka endometrial, hiki ke hoʻokaʻawale i ka endometrium, hoʻemi i ka edema, a hoʻemi i ka paʻakikī o ke ʻoki.
