Inoa | Atosiban |
Helu CAS | 90779-69-4 |
ʻAno molekala | C43H67N11O12S2 |
Kaumaha molekula | 994.19 |
Helu EINECS | 806-815-5 |
Lae paila | 1469.0±65.0 °C (Wānana ʻia) |
ʻO ka mānoanoa | 1.254±0.06 g/cm3(Wānana ʻia) |
Nā kūlana mālama | -20°C |
Solubility | H2O: ≤100 mg/mL |
ʻO Atosiban acetate kahi polypeptide cyclic disulfide i hoʻopaʻa ʻia me 9 mau amino acids.He mole oxytocin i hoʻololi ʻia ma nā kūlana 1, 2, 4 a me 8. ʻO ka N-terminus o ka peptide he 3-mercaptopropionic acid (thiol a ʻO ka hui sulfhydryl o [Cys]6 e hana i kahi paʻa disulfide), ʻo ka C-terminal. ma ke ʻano o ka amide, ʻo ka lua amino acid ma ka N-terminal he ethylated modified [D-Tyr(Et)]2, a hoʻohana ʻia ka atosiban acetate i nā lāʻau lapaʻau e like me ka vīnega Aia ma ke ʻano o ka paʻakai waikawa, maʻamau. ʻike ʻia ʻo atosiban acetate.
ʻO Atosiban kahi oxytocin a me vasopressin V1A i hui pū ʻia me ka antagonist receptor, ʻo ka oxytocin receptor i like ke ʻano me ka vasopressin V1A receptor.Ke hoʻopaʻa ʻia ka oxytocin receptor, hiki i ka oxytocin ke hana ma o ka mea loaʻa V1A, no laila pono e ālai i nā ala ʻelua ʻelua i luna i ka manawa like, a hiki i kahi antagonism o hoʻokahi mea loaʻa ke kāohi pono i ka ʻoki ʻana o ka ʻōpū.ʻO kēia kekahi o nā kumu nui e hiki ʻole ai i ka β-receptor agonists, nā mea hoʻopaʻa ala calcium a me ka prostaglandin synthase inhibitors hiki ʻole ke hoʻopaʻa maikaʻi i ka hoʻopaʻa ʻana o ka ʻōpū.
ʻO Atosiban kahi hui antagonist receptor o ka oxytocin a me ka vasopressin V1A, ua like kona ʻano kemika me nā mea ʻelua, a he kiʻekiʻe kona pilina no nā mea loaʻa, a hoʻokūkū me ka oxytocin a me ka vasopressin V1A receptors, no laila ke kāohi nei i ke ala hana o ka oxytocin a me ka vasopressin a me ka hoʻēmi ʻana. ʻoki ʻōpū.