Carbetocin to Prevent Uterine Contraction and Postpartum Hemorrhage Featured Image

ʻO Carbetocin no ka pale ʻana i ka ʻoki ʻana o ka ʻōpū a me ka hemorrhage postpartum

ʻO ka wehewehe pōkole:

Inoa: CARBETOCIN

Helu CAS: 37025-55-1

Huina molekala: C45H69N11O12S

Kaumaha molekula: 988.17

Helu EINECS: 253-312-6

Ka hoʻololi kikoʻī: D -69.0° (c = 0.25 i ka 1M acetic acid)

Puni paila: 1477.9±65.0 °C (Wanamua)

Māmā: 1.218±0.06 g/cm3 (Wānana ʻia)

Nā kūlana mālama: -15°C

ʻAno: pauka

E hoʻouna i ka leka uila iā mākou

Huahana Huahana

Inoa	CARBETOCINA
Helu CAS	37025-55-1
ʻAno molekala	C45H69N11O12S
Kaumaha molekula	988.17
Helu EINECS	253-312-6
Kahuli kiko'ī	D -69.0° (c = 0.25 i ka 1M acetic acid)
Lae paila	1477.9±65.0 °C (Wānana ʻia)
ʻO ka mānoanoa	1.218±0.06 g/cm3(Wānana ʻia)
Nā kūlana mālama	-15°C
Puka	pauda

Nā huaʻōlelo like

BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2, (SULFIDEBONDBETWEENBUTYRYL-4-YLANDCYS);BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2TRIFLUOROACETATESALT;(BUTYRYL1, TYR(ME)2)-1-CARBAOXYTOC INTRIFLUOROACETATESALT;(BUTYRYL1, TYR(ME)2)-OXYTOCIN;(BUTYRYL1,TYR(ME)2)-OXYTOCINTRIFLUOROACETATESALT;CARBETOCIN;CARBETOCINTRIFLUOROACETATESALT;(2-O-METHYLTYROSINE)-DE-AMINO-1-CARBAOXYTOCIN

Hana olaola

Carbetocin, he oxytocin (OT) analog, he oxytocin receptor agonist me ka Ki o 7.1 nM.Loaʻa i ka Carbetocin kahi pilina kiʻekiʻe (Ki=1.17 μM) no ka chimeric N-terminus o ka oxytocin receptor.Loaʻa i ka Carbetocin ka noiʻi no ka hemorrhage postpartum.Hiki i ka Carbetocin ke komo i loko o ka pale koko-lolo a loaʻa iā ia ka hana antidepressant-like me ka hoʻoulu ʻana i nā mea loaʻa oxytocin i ka CNS.

Hana

ʻO ka Carbetocin kahi mea hana lōʻihi oxytocin 8-peptide analog me nā waiwai agonist, a ua like kona mau lāʻau lapaʻau a me ka lāʻau lapaʻau me nā oxytocin kūlohelohe maoli.E like me ka oxytocin, hoʻopaʻa ʻia ka carbetocin i nā mea hoʻokipa hormone o ka ʻiʻo maʻemaʻe o ka ʻōpū, e hoʻoulu ai i ka rhythmic contractions o ka ʻōpū, e hoʻonui i kona alapine a me ka hoʻonui ʻana i ka leo uterine ma ke kumu o nā contractions o ke kumu.He haʻahaʻa ka pae o ka oxytocin receptor i loko o ka ʻōpū i ka wā hāpai ʻole, hoʻonui i ka wā hāpai, a piʻi i ka wā o ka hana.No laila, ʻaʻohe hopena o ka carbetocin i ka ʻōpū hānau ʻole, akā he hopena koʻikoʻi ka uterine contractile i ka ʻōpū hāpai a me ka ʻōpū i hana hou ʻia.

Hoʻololi Mana

Hoʻoponoponoʻia nā hoʻololi e like me ke kaʻina hana.Ma muli o ka hopena a me ka pilikia a me ke koʻikoʻi, ua helu ʻia nā hoʻololi e like me Major, Minor a me Site.He liʻiliʻi ka hopena o ka hoʻololi ʻana i ka pūnaewele i ka palekana a me ka maikaʻi o ka huahana, a no laila ʻaʻole pono ka ʻae a me ka hoʻolaha ʻana i ka mea kūʻai;ʻO nā hoʻololi liʻiliʻi he hopena kūpono i ka palekana a me ka maikaʻi o ka huahana, a pono e hoʻomaopopo i ka mea kūʻai;ʻOi aku ka hopena o nā loli nui i ka palekana a me ka maikaʻi o ka huahana, a pono e ʻae ʻia e ka mea kūʻai aku.

E like me ke kaʻina hana, hoʻomaka ka mana hoʻololi me ka noi hoʻololi kahi e wehewehe ʻia ai nā kikoʻī hoʻololi a me ke kumu no ka loli.Hana ʻia ka loiloi ma hope o ka noi, i hana ʻia e ka hoʻololi ʻana i nā keʻena kūpono.I kēia manawa, hoʻokaʻawale ʻia ka mana hoʻololi i ka pae Major, General level a me Minor level.Ma hope o ka loiloi kūpono a me ka hoʻokaʻawale ʻana, pono e ʻae ʻia ka mana hoʻololi pae āpau e ka Luna QA.Hoʻokō ʻia ka mana hoʻololi ma hope o ka ʻae ʻia e like me ka hoʻolālā hana.Ua pani ʻia ka mana hoʻololi ma hope o ka hōʻoia ʻana o QA ua hoʻokō pono ʻia ka mana hoʻololi.Inā pili ka hoʻolaha ʻana o ka mea kūʻai aku, pono e hoʻolaha ʻia ka mea kūʻai i ka manawa ma hope o ka ʻae ʻia ʻana o ka mana hoʻololi

Mua: Hoʻohana ʻia ʻo Atosiban Acetate no ka hānau mua ʻana

Aʻe: ʻO Cetrorelix Acetate e pale aku i ka ovulation mua 120287-85-6

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