Linaclotide no nā maʻi ʻeha 851199-59-2
Huahana Huahana
| Inoa | ʻO Linaclotide |
| Helu CAS | 851199-59-2 |
| ʻAno molekala | C59H79N15O21S6 |
| Kaumaha molekula | 1526.74 |
Nā huaʻōlelo like
Linaclotide;Linaclotide;LinaelotideAcetate;Linaelotide;CY-14;Liclotide;Argpessin;L-Tyrosine,L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl- L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-,cyclic(1→6),(2→10),(5→13)-tris(disulfide)
wehewehe
ʻO Linaclotide, kahi ʻano peptide synthetic i loaʻa he 14 amino acids, pili i ka ʻohana endogenous guanosine peptide ʻohana a ʻo ia wale nō ka FDA-apono ʻia GC-C (guanylate) Cyclase-C) lāʻau agonist no ka mālama ʻana i ka maʻi irritable bowel syndrome me ka constipation (IBS- C) a me ka constipation idiopathic mau loa (CIC) i nā pākeke.
Na Waiwai Kemika
ʻO Linaclotide ka pauka amorphous keʻokeʻo a keʻokeʻo;hiki ke hoʻoheheʻe iki ʻia i ka wai a me ka wai o ka sodium chloride solution (0.9%).
Pehea e hana ai
ʻO Linaclotide kahi guanylate cyclase-C receptor agonist (GCCA) me ka analgesic visceral a me ka hana endocrine.Hiki i ka linaclotide a me kāna metabolite ikaika ke hoʻopaʻa i ka mea hoʻokipa guanylate cyclase-C (GC-C) ma ka ʻili luminal o ka epithelium ʻōpū liʻiliʻi.Ma nā ʻano holoholona, hoʻemi ka linaclotide i ka ʻeha visceral a hoʻonui i ka transit gastrointestinal ma o ka hoʻāla ʻana o GC-C, a i nā kānaka, hoʻonui ka lāʻau lapaʻau i ka transit colonic.Hoʻonui ʻia ka hopena o ka hoʻoulu ʻana o GC-C i ka intracellular a me ka extracellular cGMP (cyclic guanosine monophosphate).Hiki i ka extracellular cGMP ke hoʻemi i ka hana o nā aʻalolo ʻeha a hoʻemi i ka ʻeha visceral i nā holoholona hoʻohālike.Hiki i ka cGMP intracellular ke hoʻonui i ka huna ʻana o ka chloride a me ka bicarbonate i loko o ka ʻōpū liʻiliʻi ma o ka hoʻoulu ʻana i ka CFTR (cystic fibrosis transmembrane conductance regulator), ka mea e alakaʻi ai i ka hoʻonui ʻana o ka huna ʻana o ka ʻōpū liʻiliʻi a me ka wikiwiki o ka transit intestinal liʻiliʻi.
FAQ
Ke hōʻoiaʻiʻo nei ʻoe i ka lawe ʻana i nā huahana palekana a palekana?
ʻAe, hoʻohana mau mākou i ka ʻeke hoʻoili kiʻekiʻe kiʻekiʻe.Hoʻohana pū mākou i ka hoʻopili pōʻino kūikawā no nā waiwai pōʻino a me nā mea hoʻopaʻa mālama anuanu i hōʻoia ʻia no nā mea pili wela.Hiki ke loaʻa kahi uku hou aʻe i nā mea hoʻopili kūikawā a me nā koi hoʻopaʻa maʻamau.
Pehea e pili ana i nā uku hoʻouna?
ʻO ka uku hoʻouna e pili ana i ke ala āu e koho ai e kiʻi i nā ukana.ʻO Express ke ala ʻoi aku ka wikiwiki akā ʻoi aku ka pipiʻi.ʻO ka ukana ma ke kai ka hopena maikaʻi loa no nā huina nui.Hiki iā mākou ke hāʻawi wale aku iā ʻoe inā ʻike mākou i nā kikoʻī o ka nui, ke kaumaha a me ke ala.E ʻoluʻolu e kelepona mai iā mākou no ka ʻike hou aku.
