ʻO Carbetocin no ka pale ʻana i ka ʻoki ʻana o ka ʻōpū a me ka hemorrhage postpartum
Huahana Huahana
| inoa | CARBETOCINA |
| Helu CAS | 37025-55-1 |
| ʻAno molekala | C45H69N11O12S |
| Kaumaha molekula | 988.17 |
| Helu EINECS | 253-312-6 |
| Kahuli kiko'ī | D -69.0° (c = 0.25 i ka 1M acetic acid) |
| Lae paila | 1477.9±65.0 °C (Wanamua) |
| ʻO ka mānoanoa | 1.218±0.06 g/cm3(Wānana ʻia) |
| Nā kūlana mālama | -15°C |
| Puka | pauda |
Nā huaʻōlelo like
BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2, (SULFIDEBONDBETWEENBUTYRYL-4-YLANDCYS); BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2TRIFLUOROACETATESALT; (BUTYRYL1, TYR(ME)2)-1-CARBAOXYTOC INTRIFLUOROACETATESALT; (BUTYRYL1, TYR(ME)2)-OXYTOCIN; (BUTYRYL1,TYR(ME)2)-OXYTOCINTRIFLUOROACETATESALT; CARBETOCIN; CARBETOCINTRIFLUOROACETATESALT; (2-O-METHYLTYROSINE)-DE-AMINO-1-CARBAOXYTOCIN
Hana olaola
Carbetocin, he oxytocin (OT) analog, he oxytocin receptor agonist me ka Ki o 7.1 nM. Loaʻa i ka Carbetocin kahi pilina kiʻekiʻe (Ki=1.17 μM) no ka chimeric N-terminus o ka oxytocin receptor. Loaʻa i ka Carbetocin ka noiʻi no ka hemorrhage postpartum. Hiki i ka Carbetocin ke komo i loko o ka pale koko-lolo a loaʻa iā ia ka hana antidepressant-like ma ka hoʻoulu ʻana i nā mea loaʻa oxytocin i ka CNS.
Hana
ʻO Carbetocin kahi mea hana lōʻihi o ka oxytocin 8-peptide analog me nā waiwai agonist, a ʻo kona mau lāʻau lapaʻau a me ka lāʻau lapaʻau e like me nā mea o ka oxytocin kūlohelohe. E like me ka oxytocin, hoʻopaʻa ʻia ka carbetocin i nā mea hoʻokipa hormone o ka ʻiʻo maʻemaʻe o ka ʻōpū, e hoʻoulu ai i ka rhythmic contractions o ka ʻōpū, e hoʻonui i kona alapine a me ka hoʻonui ʻana i ka leo uterine ma ke kumu o nā contractions o ke kumu. He haʻahaʻa ka pae o ka oxytocin receptor i loko o ka ʻōpū i ka wā hāpai ʻole, hoʻonui i ka wā hāpai, a piʻi i ka wā o ka hana. No laila, ʻaʻohe hopena o ka carbetocin i ka ʻōpū hānau ʻole, akā he hopena koʻikoʻi koʻikoʻi i ka ʻōpū hāpai a me ka ʻōpū i hana hou ʻia.
Hoʻololi Mana
Hoʻoponoponoʻia nā hoʻololi e like me ke kaʻina hana. Ma muli o ka hopena a me ka pilikia a me ke koʻikoʻi, ua helu ʻia nā hoʻololi e like me Major, Minor a me Site. Loaʻa ka hopena liʻiliʻi o nā hoʻololi o ka pūnaewele i ka palekana a me ka maikaʻi o ka huahana, a no laila ʻaʻole pono ka ʻae a me ka hoʻolaha ʻana i ka mea kūʻai; ʻO nā hoʻololi liʻiliʻi he hopena kūpono i ka palekana a me ka maikaʻi o ka huahana, a pono e hoʻomaopopo i ka mea kūʻai aku; ʻOi aku ka hopena o nā loli nui i ka palekana a me ka maikaʻi o ka huahana, a pono e ʻae ʻia e ka mea kūʻai.
E like me ke kaʻina hana, hoʻomaka ka mana hoʻololi me ka noi hoʻololi kahi e wehewehe ʻia ai nā kikoʻī hoʻololi a me ke kumu no ka loli. Hana ʻia ka loiloi ma hope o ka noi, i hana ʻia e ka hoʻololi ʻana i nā keʻena kūpono. I kēia manawa, hoʻokaʻawale ʻia ka mana hoʻololi i ka pae Major, General level a me Minor level. Ma hope o ka loiloi kūpono a me ka hoʻokaʻawale ʻana, pono e ʻae ʻia ka mana hoʻololi pae āpau e ka Luna QA. Hoʻokō ʻia ka mana hoʻololi ma hope o ka ʻae ʻia e like me ka hoʻolālā hana. Ua pani ʻia ka mana hoʻololi ma hope o ka hōʻoia ʻana o QA ua hoʻokō pono ʻia ka mana hoʻololi. Inā pili ka hoʻolaha ʻana o ka mea kūʻai aku, pono e hoʻolaha ʻia ka mea kūʻai aku i ka manawa ma hope o ka ʻae ʻia ʻana o ka mana hoʻololi
