Linnaclode no nā mea hana gestrointestinal 851199-59-2

ʻO Linaclode kahi Gunylate Cyclase-c resptor Agonist (GCCA) me ka hanaʻo Visceral a me nā hana Ondocrine. Hiki i nā Linanclode a me kāna metabolite ikaika i hiki ke hoʻopaʻaʻia i ka Stunytate Cyclase-C (Gc-C) i ka Epitinam o ka'ōpū. Ma nā hiʻohiʻona holoholona, ​​ua hōʻemiʻo Linaclode i ka hōʻeha a me ka hoʻonuiʻana i ka coastrointentinal ma o ka hanaʻana o GC-C, a ma keʻano he lāʻau lapaʻau e hoʻonui ai i ka transit consit colonic. Ua hoʻonuiʻia ka hopena o GC-CF-CFED intracellular a me Extracellular cgmp (Cyclic Guanosine Monooporphate). Hiki i ka CGMPElLular CGMP hiki ke hōʻemi i ka hana o nā mea i hōʻehaʻia a me ka hōʻemiʻana i nā maʻi Visceral i nā holoholona hoʻohālike. Hiki i ka cgmpular cgmp ke hoʻonui i ka moʻo o Chorde a me Bicarbonate ma ka haʻahaʻa o ka consmetine i ka uluʻana o ka consmentience.