Hoʻohana ʻia ʻo Atosiban Acetate no ka hānau mua ʻana
Huahana Huahana
| inoa | Atosiban |
| Helu CAS | 90779-69-4 |
| ʻAno molekala | C43H67N11O12S2 |
| Kaumaha molekula | 994.19 |
| Helu EINECS | 806-815-5 |
| Lae paila | 1469.0±65.0 °C (Wānana ʻia) |
| ʻO ka mānoanoa | 1.254±0.06 g/cm3(Wānana ʻia) |
| Nā kūlana mālama | -20°C |
| Ka hoʻoheheʻe | H2O: ≤100 mg/mL |
wehewehe
ʻO Atosiban acetate kahi polypeptide cyclic disulfide i hoʻopaʻa ʻia me 9 mau amino acids. He mole oxytocin i hoʻololi ʻia ma nā kūlana 1, 2, 4 a me 8. ʻO ka N-terminus o ka peptide he 3-mercaptopropionic acid (thiol a ʻO ka pūʻulu sulfhydryl o [Cys]6 e hana i kahi paʻa disulfide), ʻo ka C-terminal ma ke ʻano o ka amide, ʻo ka lua o ka amino amino i hoʻololi ʻia ma ka N-latthyterminal acid. [D-Tyr(Et)]2, a hoʻohana ʻia ka atosiban acetate i nā lāʻau lapaʻau e like me ka vīnega Aia ma ke ʻano o ka paʻakai ʻakika, i kapa ʻia ʻo atosiban acetate.
Palapala noi
ʻO Atosiban kahi oxytocin a me vasopressin V1A i hui pū ʻia me ka antagonist, ʻo ka oxytocin receptor i like ke ʻano me ka vasopressin V1A receptor. Ke hoʻopaʻa ʻia ka oxytocin receptor, hiki i ka oxytocin ke hana ma o ka loaʻa V1A, no laila pono e pale i nā ala ʻelua ʻelua i luna i ka manawa like, a hiki i kahi antagonism hoʻokahi o ka mea loaʻa ke kāohi pono i ka ʻoki ʻana o ka ʻōpū. ʻO kēia kekahi o nā kumu nui e hiki ʻole ai i ka β-receptor agonists, nā mea hoʻopaʻa ala calcium a me nā mea hoʻopaneʻe prostaglandin synthase hiki ʻole ke hoʻopaʻa pono i ka hoʻopaʻa ʻana o ka ʻōpū.
Ka hopena
ʻO Atosiban kahi hui antagonist receptor o ka oxytocin a me vasopressin V1A, ua like kona ʻano kemika me nā mea ʻelua, a he kiʻekiʻe kona pilina no nā mea hoʻokipa, a hoʻokūkū me ka oxytocin a me ka vasopressin V1A receptors, no laila ke kāohi nei i ke ala hana o ka oxytocin a me ka vasopressin a me ka hoʻohaʻahaʻa ʻana i ka ʻōpū o ka ʻōpū.
