Ste-γ-Glu-AEEA-AEEA-OSU

Ste-γ-Glu-AEEA-AEEA-OSU

ʻO Ste-γ-Glu-AEEA-AEEA-OSU kahi mole linker lipidated synthetic i hoʻolālā ʻia no ka hāʻawi ʻana i ka lāʻau lapaʻau a me nā conjugates antibody-drug (ADCs). He huelo stearoyl (Ste) hydrophobic, he γ-glutamyl motif huli ana, AEEA spacers no ka maʻalahi, a me kahi hui OSu (NHS ester) no ka hoʻohui maikaʻi ʻana.

 
Noiʻi a me nā noi:

Hoʻohana ʻia i ka synthesis prodrug a me ka hoʻolālā nanocarrier

Hoʻonui i ka pilina o ka membrane cell a me ka lawe ʻana i ka lāʻau

Hoʻoikaika i ka hoʻopili ʻana i ka uku uku kikoʻī i nā peptides, antibodies, a i ʻole nā ​​​​mea lawe

Nā hiʻohiʻona huahana (Gentolex Group):

Maʻemaʻe kiʻekiʻe, mākaukau e hoʻohui i ka ester NHS

He kūpono no ka bioconjugation a me ka noiʻi hāʻawi ʻia

He kūpono ʻo Ste-γ-Glu-AEEA-AEEA-OSU no ka hoʻomohala ʻana i ka ʻōnaehana lawe lāʻau pololei.