Daptomycin 103060-53-3 no nā maʻi lele
Huahana Huahana
| Inoa | ʻO Daptomycin |
| Helu CAS | 103060-53-3 |
| ʻAno molekala | C72H101N17O26 |
| Kaumaha molekula | 1620.67 |
| Helu EINECS | 600-389-2 |
| Lae hehee | 202-204°C |
| Lae paila | 2078.2±65.0 °C (Wanamua) |
| ʻO ka mānoanoa | 1.45±0.1 g/cm3(Wanamua) |
| kiko uila | 87 ℃ |
| Nā kūlana mālama | Hoʻopaʻa ʻia i kahi maloʻo, E mālama i loko o ka pahu hau, ma lalo o -20°C |
| Solubility | Methanol: hiki ke hoʻoheheʻe ʻia 5mg/mL |
| ʻAkika helu | (pKa) 4.00±0.10 (Wanamua) |
| Puka | pauda |
| kala kala | ʻaʻohe waihoʻoluʻu a ʻeleʻele melemele |
Nā huaʻōlelo like
N-[N-(1-Oxodecyl)-L-Trp-D-Asn-L-Asp-]-cyclo[L-Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp- Gly-D-Ser-[(3R)-3-methyl-L-Glu-]-4-(2-aminophenyl)-4-oxo-L-Abu-];N-[N-Decanoyl-L-Trp- D-Asn-L-Asp-]-cyclo[Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R)-3-methyl-L- Glu-]-3-(2-aminobenzoyl)-L-Ala-];N-(1-Oxodecyl)-L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornithinyl-L- α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl-(3R)-3-methyl-L-α-glutamyl-α,2-diamino-γ-oxo-benzenebutanoicacid(13-4)lactone; DAPTOMYCINE;Dapcin;Daptomycin,>=99%;DaptomycinReadyMadeSolution;Daptomycin(LY146032)
wehewehe
ʻO ka daptomycin antibiotic he antibiotic cyclic lipopeptide me kahi ʻano hou i unuhi ʻia mai ka broth fermentation o Streptomyces (S. reseosporus), ka mea e keakea nei i ka biosynthesis o ka peptidoglycan pā hale bacterial ma ka hoʻopilikia ʻana i ka lawe ʻana o nā waikawa amino i loko o ka membrane cell.ʻO ka hoʻololi ʻana i nā waiwai o ka membrane cytoplasmic hiki ke hoʻopau i ka hana membrane bacteria ma nā ʻano he nui a pepehi koke i ka hua bacteria Gram-positive.Ma waho aʻe o kona hiki ke hana i ka nui o nā maʻi bacteria Gram-positive e pili ana i ka maʻi, ʻoi aku ka nui o ka daptomycin no nā kānana kaʻawale i hōʻike i ke kūʻē ʻana i ka methicillin, vancomycin, a me linezolid in vitro.He hana koʻikoʻi kona, a he koʻikoʻi ko kēia waiwai i nā hopena lapaʻau no nā maʻi maʻi maʻi maʻi.ʻO ka maʻi maʻi maʻi Eosinophilic kahi maʻi kakaʻikahi a koʻikoʻi loa me nā hōʻailona e like me ke kuni, ka ʻū, pōkole o ka hanu, a me ka pilikia o ka hanu.
Ka hopena antibacterial
Loaʻa i ka Daptomycin ka hana bacteriostatic maikaʻi e kūʻē i nā ʻano bacteria kūʻē i ka lāʻau antibiotic, e like me MIC=0.06-0.5 μg/ml no ka methicillin-resistant Staphylococcus aureus (MRSA), a me ka methicillin-resistant Staphylococcus aureus (MRSA).MIC=0.0625～1μg/ml no ka bacteria, MIC=0.12～0.5μg/ml no ka oxacillin-resistant Staphylococcus epidermidis, MIC=2.5μg/ml no enterococcus kū'ē loa i nā lāʻau antibiotic aminoglycoside, MIC=2.5μg/ml no Gmr. ʻO Enterococcus he 0.5 ~ 1μg / ml, a ʻo ka MIC o Enterococcus kū'ē i nā lāʻau antibiotic glycopeptide he 1 ~ 2μg / ml.
