ʻO Caspofungin no nā maʻi antifungal
Huahana Huahana
| Inoa | Caspofungin |
| Helu CAS | 162808-62-0 |
| ʻAno molekala | C52H88N10O15 |
| Kaumaha molekula | 1093.31 |
| Helu EINECS | 1806241-263-5 |
| Lae paila | 1408.1±65.0 °C (Wānana ʻia) |
| ʻO ka mānoanoa | 1.36±0.1 g/cm3 (Wānana ʻia) |
| ʻAkika helu | (pKa) 9.86±0.26 (Wanamua) |
Nā huaʻōlelo like
CS-1171;Caspofungine;CASPOFUNGIN;CASPORFUNGIN;PneuMocandinB0,1-[(4R,5S)-5-[(2-aMinoethyl)aMino]-N2-(10,12-diMethyl-1-oxotetradecyl)-4-hydroxy- L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-;CaspofunginMK-0991;Aids058650;Aids-058650
Na Waiwai Kemika
ʻO Caspofungin ka echinocandin mua i ʻae ʻia no ka mālama ʻana i nā maʻi fungal invasive.Ua hōʻoia ʻia nā hoʻokolohua in vitro a me in vivo he hana antibacterial maikaʻi ka caspofungin e kūʻē i nā pathogens opportunistic koʻikoʻi-Candida a me Aspergillus.Hiki i ka Caspofungin ke wāwahi i ka paia o ke kelepona ma ke kāohi ʻana i ka synthesis o 1,3-β-glucan.Ma ke kino, he hopena maikaʻi ka caspofungin i ka mālama ʻana i nā candidiasis like ʻole a me ka aspergillosis.
Ka hopena
(1,3) -D-glucan synthase he mea nui ia o ka synthesis o ka paia cell fungal, a hiki i ka caspofungin ke hoʻoikaika i ka hopena antifungal ma o ka hoʻokūkū ʻole i kēia enzyme.Ma hope o ka hoʻokele intravenous, hāʻule koke ka neʻe ʻana o ka lāʻau lapaʻau i ka plasma ma muli o ka hāʻawi ʻana i nā kiko, a ukali ʻia e ka hoʻokuʻu hou ʻana o ka lāʻau mai ka ʻiʻo.Ua hoʻonui ʻia ka metabolism o ka caspofungin me ka hoʻonui ʻana i ka maʻa a ua pili pū ʻia i ka wā e kū ai me ka nui o ka nui.No laila, i mea e hoʻokō ai i nā pae therapeutic kūpono a pale aku i ka hōʻiliʻili ʻana i ka lāʻau, pono e hoʻokō ʻia kahi maʻi hoʻouka mua a ukali ʻia e kahi ʻano mālama.Ke hoʻohana nei i ka cytochrome p4503A4 inducers i ka manawa like, e like me rifampicin, carbamazepine, dexamethasone, phenytoin, etc., ua ʻōlelo ʻia e hoʻonui i ka nui o ka mālama ʻana o ka caspofungin.
Nā hōʻailona
ʻO nā hōʻailona i ʻae ʻia e FDA no ka caspofungin penei: 1. ʻO ke kuni me ka neutropenia: wehewehe ʻia e like me: ka wela> 38°C me ka helu neutrophil piha (ANC) ≤500/ml, a i ʻole me ANC ≤1000/ml a ua wānana ʻia hiki ke hoʻemi ʻia. i lalo o 500/ml.Wahi a ka ʻōlelo a ka Infectious Diseases Society of America (IDSA), ʻoiai ua mālama ʻia nā mea maʻi me ke kuni mau a me ka neutropenia me nā lāʻau lapaʻau ākea ākea, ʻōlelo ʻia nā mea maʻi kiʻekiʻe e hoʻohana i ka lāʻau antifungal empiric, me ka caspofungin a me nā lāʻau antifungal ʻē aʻe. ..2. Invasive candidiasis: Paipai ka IDSA i nā echinocandins (e like me ka caspofungin) ma ke ʻano he lāʻau koho no ka candidemia.Hiki ke hoʻohana ʻia e mālama i nā abscesses intra-abdominal, peritonitis a me nā maʻi umauma i hoʻokumu ʻia e ka maʻi Candida.3. Esophageal candidiasis: Hiki ke hoʻohana ʻia ʻo Caspofungin e mālama i ka candidiasis esophageal i nā maʻi me ka refractory a intolerance i nā lāʻau lapaʻau ʻē aʻe.Ua ʻike kekahi mau haʻawina e like ka hopena therapeutic o ka caspofungin me ka fluconazole.4. Invasive aspergillosis: Ua ʻae ʻia ʻo Caspofungin no ka mālama ʻana i ka aspergillosis invasive i nā mea maʻi me ka intolerance, kūʻē, a me ka pono ʻole o ka lāʻau antifungal nui, voriconazole.Eia naʻe, ʻaʻole ʻōlelo ʻia ka echinocandin e like me ka lāʻau lapaʻau mua.
