Hoʻoponopono ʻo Leuprorelin Acetate i ka huna ʻana o nā Hormones Gonadal

ʻO Leuprolide, goserelin, triprelin, a me nafarelin kekahi mau lāʻau lapaʻau i hoʻohana mau ʻia i ka hana lapaʻau no ka wehe ʻana i nā ovaries no ka mālama ʻana i ka maʻi maʻi umauma premenopausal a me ka maʻi prostate. (i kapa ʻia ʻo GnRH-a mau lāʻau lapaʻau), GnRH-a nā lāʻau lapaʻau e like me ka GnRH a hoʻokūkū me nā mea loaʻa GnRH pituitary. ʻO ia hoʻi, ke emi nei ka gonadotropin i hūnā ʻia e ka pituitary, kahi e alakaʻi ai i kahi emi nui o ka hormone sex huna ʻia e ka ovary.

ʻO ka Leuprolide he gonadotropin-releasing hormone (GnRH) analog, he peptide i haku ʻia me 9 amino acids. Hiki i kēia huahana ke pale pono i ka hana o ka pituitary-gonadal system, ke kū'ē i nā enzymes proteolytic a me ka pili i ka pituitary GnRH receptor iʻoi aku ka ikaika ma mua o GnRH, aʻo ka hana o ka hoʻouluʻana i ka hoʻokuʻuʻana o ka hormone luteinizing (LH) ma kahi o 20 mau manawa o GnRH. ʻOi aku ka ikaika o ka hopena i ka hana pituitary-gonad ma mua o GnRH. I ka wā mua o ka mālama ʻana, hiki ke hoʻonui ʻia ka follicle stimulating hormone (FSH), LH, estrogen a i ʻole androgen, a laila, ma muli o ka emi ʻana o ka pane ʻana o ka pituitary gland, ua kāohi ʻia ka huna ʻana o FSH, LH a me ka estrogen a i ʻole androgen. ʻO nā maʻi moe (e like me ka maʻi prostate, endometriosis, etc.) he hopena lapaʻau.

I kēia manawa, hoʻohana nui ʻia ka paʻakai acetate o ka leuprolide i ka maʻi maʻi, no ka mea, ʻoi aku ka paʻa o ka hana o ka leuprolide acetate i ka mahana o ka lumi. Pono e hoʻolei ʻia ka wai. Hiki ke hoʻohana ʻia no ka mālama ʻana i ka lāʻau lapaʻau o ka endometriosis a me ka fibroids uterine, ka wā ʻōpio precocious waena, ka maʻi maʻi premenopausal a me ka maʻi prostate, a no ka hoʻokahe koko ʻana o ka ʻōpū i contraindicated a ʻaʻole pono no ka lāʻau hormone maʻamau. Hiki ke hoʻohana ʻia ma ke ʻano he lāʻau lapaʻau ma mua o ka wehe ʻana o ka endometrial, hiki ke hoʻokaʻawale i ka endometrium, hoʻemi i ka edema, a hoʻemi i ka paʻakikī o ke ʻoki.