Ganirelix Acetate Peptide API
Huahana Huahana
| inoa | ʻO Ganirelix Acetate |
| Helu CAS | 123246-29-7 |
| ʻAno molekala | C80H113ClN18O13 |
| Kaumaha molekula | 1570.34 |
Nā huaʻōlelo like
Ac-DNal-DCpa-DPal-Ser-Tyr-DHar(Et2)-Leu-Har(Et2)-Pro-DAla -NH2;Ganirelixum;ganirelix Acetate; GANIRELIX; Ganirelix Acetate USP/EP/
wehewehe
ʻO Ganirelix kahi pūhui decapeptide synthetic, a ʻo kāna paʻakai acetate, Ganirelix acetate he mea hoʻokuʻu gonadotropin-releasing hormone (GnRH) receptor antagonist. ʻO ke kaʻina amino acid: Ac-D-2Nal-D-4Cpa-D-3Pal-Ser-Tyr-D-HomoArg(9,10-Et2)-Leu-L-HomoArg(9,10-Et2)-Pro-D- Ala-NH2. ʻO ka mea maʻamau, hoʻohana ʻia ia i nā wahine e hoʻohana ana i nā polokalamu hoʻoulu ovarian i kōkua ʻia i ka ʻenehana reproductive e pale i ka piʻi ʻana o ka hormone luteinizing premature a me ka mālama ʻana i nā maʻi hānai ma muli o kēia kumu. Loaʻa ka lāʻau lapaʻau i nā hiʻohiʻona o ka liʻiliʻi o nā hopena ʻino, kiʻekiʻe ka nui o ka hāpai ʻana a me ka manawa mālama pōkole, a loaʻa nā pōmaikaʻi i ka hoʻohālikelike ʻia me nā lāʻau like i ka hana lapaʻau.
Hana lāʻau lapaʻau
ʻO ka hoʻokuʻu pulsatile o ka hormone hoʻokuʻu gonadotropin (GnRH) e hoʻoulu i ka synthesis a me ka huna ʻana o LH a me FSH. ʻO ke alapine o nā pulu LH i ka waena a me ka hope o ka follicular phases ma kahi o 1 i kēlā me kēia hola. Hōʻike ʻia kēia mau puʻupuʻu i ka piʻi ʻana o ka serum LH. I loko o ka manawa waena, ʻo ka hoʻokuʻu nui ʻana o GnRH ke kumu o ka piʻi ʻana o LH. Hiki i ka piʻi ʻana o ka LH midmenstrual ke hoʻoulu i nā pane physiological, e like me: ovulation, oocyte meiotic resumption, a me ka corpus luteum formation. ʻO ka hoʻokumu ʻana o ka corpus luteum ke kumu e piʻi ai nā pae progesterone serum, ʻoiai hāʻule nā pae estradiol. ʻO Ganirelix acetate kahi GnRH antagonist e hoʻokūkū i nā mea hoʻokipa GnRH ma nā gonadotrophs pituitary a me nā ala transduction ma hope. Hoʻopuka ʻo ia i kahi hoʻopaʻapaʻa wikiwiki a hiki ke hoʻohuli i ka huna ʻana o ka gonadotropin. ʻOi aku ka ikaika o ka hopena o ka ganirelix acetate ma ka huna ʻana o ka pituitary LH ma mua o ka FSH. ʻAʻole hiki i Ganirelix acetate ke hoʻoulu i ka hoʻokuʻu mua o nā gonadotropins endogenous, e like me ka antagonism. Loaʻa ka hoʻihoʻi piha ʻana o nā pae pituitary LH a me FSH i loko o 48 mau hola ma hope o ka pau ʻana o ka acetate ganirelix.
