ʻO Caspofungin no nā maʻi antifungal
Huahana Huahana
| inoa | Caspofungin |
| Helu CAS | 162808-62-0 |
| ʻAno molekala | C52H88N10O15 |
| Kaumaha molekula | 1093.31 |
| Helu EINECS | 1806241-263-5 |
| Lae paila | 1408.1±65.0 °C (Wānana ʻia) |
| ʻO ka mānoanoa | 1.36±0.1 g/cm3(Wanamua) |
| ʻO ka ʻakika coefficient | (pKa) 9.86±0.26 (Wanamua) |
Nā huaʻōlelo like
CS-1171;Caspofungine;CASPOFUNGIN;CASPORFUNGIN;PneuMocandinB0,1-[(4R,5S)-5-[(2-aMinoethyl)aMino]-N2-(10,12-diMethyl -1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-;CaspofunginMK-0991;Aids058650;Aids-058650
Na Waiwai Kemika
ʻO Caspofungin ka echinocandin mua i ʻae ʻia no ka mālama ʻana i nā maʻi fungal invasive. Ua hōʻoia nā hoʻokolohua in vitro a me in vivo he hana antibacterial maikaʻi ka caspofungin e kūʻē i nā pathogens opportunistic koʻikoʻi-Candida a me Aspergillus. Hiki i ka Caspofungin ke wāwahi i ka paia o ke kelepona ma ke kāohi ʻana i ka synthesis o 1,3-β-glucan. Ma ke kino, he hopena maikaʻi ka caspofungin i ka mālama ʻana i nā ʻano candidiasis a me ka aspergillosis.
Ka hopena
ʻO (1,3) -D-glucan synthase kahi mea nui o ka hoʻopili ʻana i ka paia cell fungal, a hiki i ka caspofungin ke hana i kahi hopena antifungal ma o ka hoʻokūkū ʻole i kēia enzyme. Ma hope o ka hoʻokele intravenous, hāʻule koke ka neʻe ʻana o ka lāʻau lapaʻau i ka plasma ma muli o ka hāʻawi ʻana i ka ʻiʻo, a ma hope o ka hoʻokuʻu hou ʻana o ka lāʻau mai ka ʻiʻo. Ua hoʻonui ʻia ka metabolism o ka caspofungin me ka hoʻonui ʻana i ka maʻi a ua pili pū ʻia i ka manawa e kū ai me nā ʻano he nui. No laila, i mea e hoʻokō ai i nā pae therapeutic kūpono a pale i ka hōʻiliʻili ʻana i ka lāʻau, pono e hoʻokō ʻia kahi maʻi hoʻouka mua a ukali ʻia e kahi ʻano mālama. Ke hoʻohana nei i ka cytochrome p4503A4 inducers i ka manawa like, e like me rifampicin, carbamazepine, dexamethasone, phenytoin, etc., ua ʻōlelo ʻia e hoʻonui i ka nui o ka mālama ʻana o ka caspofungin.
Nā hōʻailona
ʻO nā hōʻailona i'āponoʻia e FDA no ka caspofungin: 1. ʻO ke kuni me ka neutropenia: weheweheʻia e like me: ka wela> 38 ° C me ka helu neutrophil piha (ANC) ≤500 / ml, aiʻole me ANC ≤1000 / ml a ua wānanaʻia e hiki ke hoʻemiʻia i lalo o 500 / ml. Wahi a ka ʻōlelo aʻoaʻo a ka Infectious Diseases Society of America (IDSA), ʻoiai ua mālama ʻia nā mea maʻi me ke kuni mau a me ka neutropenia me nā lāʻau lapaʻau ākea ākea, ua ʻōlelo ʻia nā mea maʻi kiʻekiʻe e hoʻohana i ka empiric antifungal therapy, me ka caspofungin a me nā lāʻau antifungal ʻē aʻe. . 2. Invasive candidiasis: Paipai ʻo IDSA i nā echinocandins (e like me ka caspofungin) ma ke ʻano he lāʻau koho no ka candidemia. Hiki ke hoʻohana ʻia e mālama i nā abscesses intra-abdominal, peritonitis a me nā maʻi umauma i hoʻokumu ʻia e ka maʻi Candida. 3. Esophageal candidiasis: Hiki ke hoʻohana ʻia ʻo Caspofungin e mālama i ka candidiasis esophageal i nā poʻe maʻi me ka refractory a i ʻole intolerance i nā lāʻau lapaʻau ʻē aʻe. Ua ʻike ʻia kekahi mau haʻawina e like ka hopena therapeutic o ka caspofungin me ka fluconazole. 4. Invasive aspergillosis: Ua ʻae ʻia ʻo Caspofungin no ka mālama ʻana i ka aspergillosis invasive i nā maʻi me ka intolerance, kūʻē, a me ka pono ʻole o ka lāʻau antifungal nui, voriconazole. Eia naʻe, ʻaʻole ʻōlelo ʻia ka echinocandin e like me ka lāʻau lapaʻau mua.
