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Hana pharmacological
ʻO kēia lāʻau lapaʻau kahi phosphodierakeseese helu 5 (pde5) inhibitor. Hiki i ka hoʻokele kino o kēia lāʻau lapaʻau ke hoʻomaikaʻi maikaʻi i ka maikaʻi a me ka lōʻihi o keʻano o ke olaʻana i ke ola kāne i ke ola kāne kāne me nā mea maʻi kāne. ʻO ka hoʻomakaʻana a me ka mālamaʻana i ka hana o ka penikala e pili ana i ka hoʻomahaʻana o ka cevernosh collast Mālama kēia lāʻau lapaʻau i ka decomposition o CGMP i ka hoʻohālikelikeʻana i ka chosnotsum o ka cgpus, a me keʻano o ka penis. Hoʻohālikelike me Phosphodeeseseese isozsmes 1, 2, 3, a me 6, a me 6, a me 6, a me 6, a me 6, a me 6, a me 6, a me 6, a 6 Hōʻike kekahi mauʻikepili i kona kohoʻana a me ka hopena inhibitory ma luna o PhosphodieSteesesese Type phosphosesteree

Nā lāʻau lapaʻau a me nā noi

1 ʻO ka hypotensi, nā loli eʻike ai, ke poʻo, ke poʻo, fuclus flamuning, priapism). Pono e paleʻia kēia lāʻau lapaʻau i ka hui pū me RitionIr a me Indinavir. I ka wā e hui pū ai me Erythromycin,ʻo Ketoazole, a me ITraconzozle
2. E lawe ana nā poʻe maʻi i nā mea pono a iʻole ka loaʻaʻana o ka nitric oxide donor e pale i kēia lāʻau lapaʻau. ʻO keʻano o kāna hana o ka hana e hoʻonui hou i kaka hoʻohālikelikeʻana o CGMP, e hopena ana i ka hopena antihyperte i hoʻonuiʻia a hoʻonuiʻia ka naʻau naʻau. Ke hoʻohana pūʻia me nā blockers α-resptor, hiki iā ia ke hoʻonui i ka hopena Antihypertenson a alakaʻi i ka hypotension. No laila, ua pāpāʻia ka hoʻohanaʻana o kēia lāʻau lapaʻau no ka poʻe e hoʻohana ana i nā lawena Haʻawina noʻo ka hoʻohanaʻana i loko o ka poʻe lawe aku iā α-loaʻa nā blocker. ʻO kahi meaʻai momona-momona

Lakanana Hana
Ua hoʻopiliʻiaʻo ia ma hope o ka hoʻokele waha,ʻo ka biovatelabile o ka'āina o ka'āinaʻo 15%, a me ka manawa maʻamau ke nānā akuʻo 1h (0.5-2h). ʻO ka hopena o ka'āina he 10mg a 20mg paha,ʻo ka manawa kiʻekiʻeʻo 0.9h a me 0.7h, a me 21,2 ʻO ka uku o ka protein i loaʻa i kēia lāʻau lapaʻau e pili ana i ka 95%. 1.5th ma hope o kahiʻano o keʻano he 20 mg,ʻo kaʻikepili o ka lāʻau lapaʻau i loko o ka semen he 0.00018% o ka pā. ʻO ka lāʻau lapaʻau nui ka metabilin ma ka Lie e Cytochrome P450 ʻO ka metabolite nuiʻo M1 i hoʻokumuʻia e ka dethylation o keʻano o ka papezine o kēia lāʻau lapaʻau. ʻO M1 hoʻi ka hopena o ka hoʻopiliʻana i nā phoshodeteemake ai i ka 2 (e pili ana i 7% o ka hopena kiʻekiʻe), aʻo kona koko ke heluheluʻia ke koko. , a hiki ke lilo hou i ka metabolilized. Nā kumukūʻai excretion o nā lāʻau lapaʻau ma keʻano o nā metabolites i nā feces a me ka urine e pili ana iā 91% a me ka 95% a me ka 4% a me 2%. ʻO ka nui o ka hoʻomaʻemaʻe pihaʻana o ka nui, 50 l i hoʻokahi hola, a me nā hapa hapa o ka nui o ka makua makua a me nā hola he 5 a 5 paha.