Tadalafil 171596-29-5 e mālama pono i ka dyrefunction dysfunction ma nā kāne

Tadalafil Ua hoʻohana nuiʻia ia ma ka mālamaʻana i ka mālamaʻana o ke kāne e deftile dysfunction mai ka makahiki 2003, me ka inoaʻo Cetiano (cialitis. I Iune 2009,ʻo ka FDA iʻaeʻiaʻo Tadalafil maʻAmelika Hui PūʻIa no ka Hale Hōʻikeʻikeʻo Flidey Arolpertension (Pah) ma lalo o ka inoa kālepa Adcirca. Ua hoʻokomoʻiaʻo Tadalafil i ka makahiki 2003 e like me ka lāʻau lapaʻau no ka mālamaʻana o ED. Loaʻa iā ia ka hopena 30 mau minuke ma hope o ka hoʻokeleʻana, akāʻo kāna hopena maikaʻi loa he 2h ma hope o ka onsset ka mea i loaʻa i ka meaʻai. ʻO ka Dose o Tadalafil he 10 a 20 Mg,ʻo ka'ōlelo mua i'ōleloʻia he 10 mg, a hoʻoponoponoʻia ka paneʻana e like me ka paneʻana o ka mea maʻi. Ua hōʻikeʻia nā haʻawina mua ma hope o ka hoʻokele waha o ka mea hoʻokele o 10 a 20 mg o Tadalafil no 12 mau makahiki, he 67% a me 81% a me 81%. Ua hōʻikeʻia nā haʻawina he nui uaʻoi aku ka maikaʻi o Tadalafil

ʻO ka Dysfunction Dysfunction:ʻO Tadalafil e koho ana i kahi phosphodiesekesese koho 5 (PDE5) e like me keʻano o keʻano. Ma lalo o ka hana o ka hoʻoikaikaʻana o ka moekolohe, nitric cynthase ʻAʻole i hana i ka Goyanted Goyantete, kahi e hoʻohuli ai iā GunosIne Turphosphate-Doupent calclicate calclight ʻO ka phosphodiesikesike i ka 5 (PD5) degrades cgmp i loko o nā huahana waiwai, e hana ana i ka penis i kahi kūlana palupalu. ʻO Tadalafil i hoʻopaʻaʻia i ka degradation o ka pde5, e alakaʻi ana i ka hōʻiliʻili o ka cgmp, e hōʻoluʻolu i keʻano ikaika. Mai ka wāʻole nā ​​mea hoʻonaninani, hoʻohanaʻia me ka hoʻohanaʻana me Tadalafil e hoʻonui nui i ka pae o CGMP a alakaʻi i ka hypotension. No laila, hoʻohanaʻia ka hoʻohanaʻana o nā meaʻelua iʻelua mau mea i ka hoʻomaʻamaʻa clinical.

Hanaʻo Tadalafil e nā papa kuhikuhi. Hoʻomoeʻiaʻo GMP, no laila ua hui pūʻia nā hoʻohanaʻana me nā nitrates e hōʻeha i kahi hāʻule o ke koko a hoʻonui i ka hopena o ka syncope. E hōʻemi nā mea i nā kd3pa4 i ka biovaila Ma kahi mamao,ʻaʻohe mea hōʻike e pili ana i nā parametertic pharmacoconico