ʻO Sildenafil Citrate e mālama ana i ka erectile dysfunction 171599-83-0
Huahana Huahana
| inoa | ʻO Sildenafil Citrate |
| Helu CAS | 171599-83-0 |
| ʻAno molekala | C28H38N6O11S |
| Kaumaha molekula | 666.70 |
| Helu EINECS | 200-659-6 |
| ʻO Merck | 14,8489 |
| ʻO ka mānoanoa | 1.445g/cm3 |
| Kūlana mālama | 2-8°C |
| Puka | Pauda |
| kalakala | Keʻokeʻo |
| Ka hoʻoheheʻe wai | DMSO: >20mg/mL |
Nā huaʻōlelo like
Viagra, Sildenafil citrate; 1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazinecitratessalt; 5-[2-Ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[5,4-e]pyrimidin-7-onecitratessalt; 1-[[3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl) -4-ethoxyphenyl]sulfonyl]-4-methylpiperazine,2-hydroxy-1,2,3-propanetricarboxylate; SildenafilCitrate(100mg); Sildenafilcitrate,>=99%;Sildenafilcitrate,Profesionalsupply; 5-[2-Ethoxy-5-[(4-methyl-piperazin-1-yl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-onecitrate
Ka hopena lāʻau lapaʻau
Hana lāʻau lapaʻau
ʻO ka Sildenafil citrate he mea hoʻopiʻi koho 5-phosphodiesterase e hoʻonui i ka nitric oxide-dependent, cyclic guanosine monophosphate-mediated pulmonary vasodilation ma ke kāohiʻana i ka haʻihaʻiʻana o ka cyclic guanosine monophosphate. Ma waho aʻe o ka hoʻonui pololei ʻana o nā kīʻaha koko pulmonary, hiki iā ia ke pale a hoʻohuli paha i ka hoʻoponopono hou ʻana.
Nā Waiwai Lapaʻau a me nā noi
ʻO Sildenafil citrate, inoa kālepa Viagre, iʻike nuiʻiaʻo Viagra, he cyclic guanosine monophosphate (cGMP) -specific phosphodiesterase type 5 (PDE5) inhibitor hiki ke hoʻonui i ke kūkuluʻana ma hope o ka lawelawe waha. Hiki i ka Sildenafil citrate ke hoʻonui i ka hopena o ka nitric oxide (NO) ma ke kāohi ʻana i ke ʻano 5 phosphodiesterase e decomposes cyclic guanosine monophosphate (cGMP) i loko o ka corpus cavernosum. E hoʻonui i ke kiʻekiʻe o cGMP i loko o ka corpus cavernosum, e hoʻomaha i ka ʻiʻo maʻemaʻe i loko o ka corpus cavernosum, e hoʻonui i ke kahe o ke koko, e hoʻolōʻihi i ka manawa o ke kūkulu ʻana i ka penis a hoʻonui i ka paʻa. No nā maʻi impotence me ka erectile dysfunction. Lawe nā mākua i ka 50 mg ma ka waha i kēlā me kēia manawa, a hiki i 1 manawa i ka lā, a hoʻohana iā ia e like me 1 hola ma mua o ka moe kolohe. ʻO ka nui loa he 0.1g i kēlā me kēia manawa.
Ma nā haʻawina vivo
I loko o nā ʻīlio anestheticized, hoʻonui ʻo Sildenafil citrate i ka hana penile erectile ma lalo o ka hoʻoulu ʻana o ke aʻalolo pelvic ma ke ana ʻana i ke kaomi intracavernous. ʻO ka Sildenafil citrate ka mea i hoʻohuli i ka hoʻomaha hoʻomaha i hoʻoulu ʻia i ka carbamoylcholine a pale i ka hoʻokumu ʻana o ka superoxide i loko o ka ʻiʻo cavernosal o nā rapeti hypercholesterolemic. I nāʻiole Sprague-Dawley, hoʻomaikaʻi ʻo Sildenafil i ka hana erectile i kahi manawa-dose-dependent, me ka hoʻihoʻi kiʻekiʻe loa i ka lā 28 ma kahi ʻano o 20 mg / kg i kēlā me kēia lā. I nāʻiole Sprague-Dawley, hoʻoponopono ʻia ʻo Sildenafil i hopena i ka mālama ʻana i ka ratio collagen muscle maʻemaʻe a me ka mālama ʻana i ka ʻōlelo CD31 a me eNOS. Ma nāʻiole Sprague-Dawley, ua ho'ēmi nuiʻo Sildenafil i ka helu apoptotic a hoʻonui i ka phosphorylation o akt a me eNOS i hoʻohālikelikeʻia me ka pūʻulu mana.
