ʻO ka lāʻau lapaʻau
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Fmoc-Lys(Pal-Glu-OtBu)-OH
ʻO Fmoc-Lys (Pal-Glu-OtBu) -OH kahi papa hale kūkulu hale lipidated amino acid i hoʻolālā ʻia no ka conjugation peptide-lipid. Hōʻike ia i ka lysine pale ʻia ʻo Fmoc me kahi kaulahao ʻaoʻao palmitoyl-glutamate, hoʻonui i ka pili o ka membrane a me ka bioavailability.
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Fmoc-His-Aib-OH
ʻO Fmoc-His-Aib-OH kahi papa hale dipeptide i hoʻohana ʻia i ka synthesis peptide, e hui pū ana i ka histidine pale ʻia Fmoc a me Aib (α-aminoisobutyric acid). Hoʻokomo ʻo Aib i ka conformational rigidity, i mea waiwai no ka hoʻolālā ʻana i nā peptides helical a paʻa.
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Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH
ʻO Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH kahi ʻāpana tetrapeptide pale ʻia i hoʻohana ʻia i ka peptide synthesis a me ka hoʻomohala ʻana i ka lāʻau. Loaʻa iā ia nā pūʻulu hana i pale ʻia no ka hoʻopili stepwise a me nā hiʻohiʻona Aib (α-aminoisobutyric acid) e hoʻonui ai i ka paʻa helix a me ka rigidity conformational.
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Ste-γ-Glu-AEEA-AEEA-OSU
ʻO Ste-γ-Glu-AEEA-AEEA-OSU kahi mole linker lipidated synthetic i hoʻolālā ʻia no ka hāʻawi ʻana i ka lāʻau lapaʻau a me nā conjugates antibody-drug (ADCs). He huelo stearoyl (Ste) hydrophobic, he γ-glutamyl motif huli ana, AEEA spacers no ka maʻalahi, a me kahi hui OSu (NHS ester) no ka hoʻohui maikaʻi ʻana.
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Fmoc-Ile-αMeLeu-Leu-OH
ʻO Fmoc-Ile-αMeLeu-Leu-OH kahi poloka hale tripeptide pale synthetic e hōʻike ana i ka leucine α-methylated, i hoʻohana mau ʻia i ka hoʻolālā lāʻau peptide e hoʻomaikaʻi i ke kūpaʻa metabolic a me ka koho koho.
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Dodecyl Phosphocholine (DPC)
ʻO Dodecyl Phosphocholine (DPC) kahi mea hoʻomaʻemaʻe zwitterionic synthetic i hoʻohana nui ʻia i ka noiʻi protein membrane a me ka biology structural, ʻoi loa i ka NMR spectroscopy a me crystallography.
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Donidalorsen
ʻO Donidalorsen API kahi antisense oligonucleotide (ASO) ma lalo o ka hoʻokolokolo ʻana no ka mālama ʻana i ka angioedema hereditary (HAE) a me nā kūlana inflammatory pili. Ua aʻo ʻia i loko o ka pōʻaiapili o nā lāʻau lapaʻau i hoʻopaʻa ʻia i ka RNA, me ka manaʻo e hōʻemi i ka hōʻike ʻana oplasma prekallikrein(KLKB1 mRNA). Hoʻohana ka poʻe noiʻi iā Donidalorsen e ʻimi i nā mīkini silencing gene, pharmacokinetics hilinaʻi dose, a me ka hoʻomalu lōʻihi o ka ʻāʻī ʻana o bradykinin.
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Fitusiran
ʻO Fitusiran API kahi RNA interfering liʻiliʻi liʻiliʻi (siRNA) i noiʻi nui ʻia ma ke kahua o ka hemophilia a me nā maʻi coagulation. Huli ia i kaantithrombin (AT a i ʻole SERPINC1)gene i loko o ke ake e ho'ēmi i ka hana antithrombin. Hoʻohana ka poʻe noiʻi iā Fitusiran e ʻimi i nā hana RNA interference (RNAi), silencing gene kikoʻī kikoʻī o ka ate, a me nā hoʻolālā therapeutic novel no ka hoʻoponopono hou ʻana i ka coagulation i nā maʻi hemophilia A a me B, me ka ʻole a i ʻole nā mea hoʻopaneʻe.
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Givosiran
ʻO Givosiran API kahi RNA interfering liʻiliʻi liʻiliʻi (siRNA) i aʻo ʻia no ka mālama ʻana i ka porphyria hepatic acute (AHP). Kuhi nui ia i kaALAS1gene (aminolevulinic acid synthase 1), i komo i ke ala biosynthesis heme. Hoʻohana nā mea noiʻi iā Givosiran e noiʻi i nā lāʻau lapaʻau e pili ana i ka RNA interference (RNAi), silencing gene i hoʻopaʻa ʻia i ka ate, a me ka modulation o nā ala metabolic e pili ana i ka porphyria a me nā maʻi genetic pili.
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Plozasiran
ʻO Plozasiran API kahi RNA interfering liʻiliʻi liʻiliʻi (siRNA) i hoʻomohala ʻia no ka mālama ʻana i ka hypertriglyceridemia a me nā maʻi cardiovascular a me ka metabolic pili. Huli ia i kaAPOC3gene, ka mea e hoʻopili i ka apolipoprotein C-III, kahi mea hoʻoponopono koʻikoʻi o ka metabolism triglyceride. I ka noiʻi ʻana, hoʻohana ʻia ʻo Plozasiran e aʻo i nā hoʻolālā hoʻohaʻahaʻa lipid e pili ana i ka RNAi, ka kikoo-silencing kikoʻī, a me nā lāʻau lōʻihi no nā kūlana e like me ka familial chylomicronemia syndrome (FCS) a me ka dyslipidemia hui ʻia.
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Zilebesiran
ʻO Zilebesiran API kahi noiʻi liʻiliʻi liʻiliʻi interfering RNA (siRNA) i kūkulu ʻia no ka mālama ʻana i ka hypertension. Huli ia i kaAGTgene, e hoʻopili ana i ka angiotensinogen—he mea nui o ka ʻōnaehana renin-angiotensin-aldosterone (RAAS). Ma ka noiʻi, hoʻohana ʻia ʻo Zilebesiran e aʻo i nā ala hoʻoheheʻe gene no ka mālama ʻana i ke koko lōʻihi, nā ʻenehana lawe RNAi, a me ka hana ākea o ke ala RAAS i nā maʻi cardiovascular a me ka renal.
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ʻO Caspofungin no nā maʻi antifungal
Ka inoa: Caspofungin
Helu CAS: 162808-62-0
Kumu molekala: C52H88N10O15
Kaumaha molekula: 1093.31
Helu EINECS: 1806241-263-5
Puni paila: 1408.1±65.0 °C (Wanamua)
Māmā: 1.36±0.1 g/cm3 (Wānana ʻia)
ʻAkika helu helu: (pKa) 9.86±0.26 (Wanamua)