ʻO Orlistat 96829-58-2 E hōʻemi ana i ka absorption o ka momona Sietary, ka hopena i ka poho kaumaha.

Waiwai

ʻO ka pauka crystalline keʻokeʻo, aneane hiki ʻole ke hoʻoheheʻe ʻia i ka wai, hiki ke hoʻoheheʻe ʻia i ka chloroform, hiki ke hoʻoheheʻe ʻia i ka methanol a me ka ethanol, maʻalahi ke pyrolyze, ʻo ka helu heheʻe he 40 ℃ ~ 42 ℃. ʻO kāna mole he diastereomer i loaʻa nā kikowaena chiral ʻehā, ma ka hawewe nalu o 529nm, ʻo kāna solution ethanol he ʻano ʻino ʻino.

Ke ano o ka hana

ʻO Orlistat kahi mea hana lōʻihi a ikaika hoʻi i ka gastrointestinal lipase inhibitor, ka mea i hoʻopau i nā enzyme ʻelua i luna ma o ka hana ʻana i kahi paʻa covalent me ka pūnaewele serine ikaika o lipase i loko o ka ʻōpū a me ka ʻōpū liʻiliʻi. ʻAʻole hiki i nā enzyme inactivated ke wāwahi i ka momona i loko o ka meaʻai i loko o nā ʻakika momona manuahi a me ka Chemicalbook glycerol hiki ke hoʻomoʻa ʻia e ke kino, ma laila e hōʻemi ai i ka ʻai momona a hoʻemi i ke kaumaha. Eia kekahi, ua ʻike kekahi mau haʻawina ʻo ka orlistat ke kāohi nei i ka absorption intestinal o ka cholesterol ma ke kāohi ʻana i ka niemann-pick C1-like protein 1 (niemann-pickC1-like1, NPC1L1).

Nā hōʻailona

Hōʻike ʻia kēia huahana i hui pū ʻia me kahi meaʻai hypocaloric haʻahaʻa no ka mālama lōʻihi ʻana i ka poʻe momona a me ke kaumaha nui, me ka poʻe i loaʻa nā kumu pilikia e pili ana i ka momona. Loaʻa i kēia huahana ka mana paona lōʻihi (ka pohō kaumaha, mālama paona a me ka pale ʻana i ka rebound). ʻO ka lawe ʻana i ka orlistat hiki ke hōʻemi i nā kumu pilikia pili i ka momona a me ka loaʻa ʻana o nā maʻi e pili ana i ka momona, e like me ka hypercholesterolemia, type 2 diabetes, impaired glucose tolerance, hyperinsulinemia, hypertension, a me ka hoʻohaʻahaʻa ʻana i nā momona momona.

Nā Pili Lapaʻau

Hiki ke hoʻemi i ka absorption o nā huaora A, D a me E. Hiki ke hoʻonui ʻia me kēia huahana i ka manawa like. Inā ʻoe e hoʻomākaukau ana i nā huaora A, D a me E (e like me kekahi mau multivitamins), pono ʻoe e lawe i kēia huahana 2 mau hola ma hope o ka lawe ʻana i kēia huahana a i ka wā moe. Pono paha ka poʻe me ka maʻi maʻi type 2 e hoʻemi i ka nui o nā lāʻau hypoglycemic waha (e laʻa, sulfonylureas). ʻO ka hui pū ʻana me ka cyclosporine hiki ke hopena i ka emi ʻana o ka nui o ka plasma plasma o ka hope. ʻO ka hoʻohana like ʻana o ka amiodarone hiki ke hoʻemi i ka absorption o ka mea hope a hōʻemi i ka pono.