Fmoc-Thr(tBu)-Phe-OH

Fmoc-Thr(tBu)-Phe-OH

Noi noiʻi:
ʻO Fmoc-Thr(tBu)-Phe-OH kahi poloka hale dipeptide i hoʻohana mau ʻia i loko o ka solid-phase peptide synthesis (SPPS). Mālama ka pūʻulu Fmoc (9-fluorenylmethyloxycarbonyl) i ka N-terminus, aʻo ka hui tBu (tert-butyl) e pale i ke kaulahao ʻaoʻao hydroxyl o threonine. Hoʻopaʻa ʻia kēia dipeptide pale no kāna kuleana i ka hoʻomaʻamaʻa ʻana i ka elongation peptide kūpono, e hōʻemi ana i ka racemization, a me ka hoʻohālikelike ʻana i nā kumu kikoʻī kikoʻī i ka hoʻolālā protein a me nā haʻawina pili.

Hana:
Hana ʻo Fmoc-Thr(tBu)-Phe-OH ma ke ʻano he precursor no ka synthesizing peptides i loaʻa nā koena threonine a me phenylalanine, he mea nui ia no ka hana ʻana i nā paʻa hydrogen a me nā pilina hydrophobic. Hāʻawi ke kaulahao ʻaoʻao threonine i ka polarity a me nā pūnaewele phosphorylation, ʻoiai ʻo ka phenylalanine e hoʻohui i ke ʻano aromatic a me ka paʻa o ke kūkulu. He mea pono kēia hui ʻana i ka hoʻolālā ʻana i nā peptides no nā hoʻokolohua biological, nā haʻawina hoʻopaʻa paʻa ʻana, a me nā noi ʻike lāʻau.