Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH

Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH

Noi noiʻi:
ʻO kēia pūhui he lysine derivative i hoʻohana ʻia i ka peptide synthesis a me ka hoʻomohala ʻana i ka lāʻau conjugate. Hōʻike ia i kahi pūʻulu Fmoc no ka pale N-terminal, a me kahi hoʻololi ʻaoʻao-chain me Eic(OtBu) (eicosanoic acid derivative), γ-glutamic acid (γ-Glu), a me AEEA (aminoethoxyethoxyacetate). Hoʻolālā ʻia kēia mau ʻāpana e aʻo i nā hopena lipidation, spacer chemistry, a me ka hoʻokuʻu ʻana i ka lāʻau. Ua noiʻi nui ʻia ma ka pōʻaiapili o nā hoʻolālā prodrug, nā mea hoʻopili ADC, a me nā peptides pili membrane.

Hana:
Hana ʻo Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH ma ke ʻano he hale kūkulu hale no ka synthesizing lipid-modified peptides a i ʻole nā ​​​​pūnaewele lawe lāʻau. Hoʻonui ka Eic moiety i ka lipophilicity a me ka paʻa ʻana o ka membrane; Hoʻohui ʻo γ-Glu i ka paʻa enzymatic a me ka hiki ke hoʻopaʻa ʻia; a ʻo AEEA ke hana ma ke ʻano he mea hoʻopili hydrophilic maʻalahi. Hoʻohui pū ʻia, hiki iā lākou ke hana i nā peptides me ka hoʻonui ʻana i ka cellular uptake, hoʻonui i ka hapalua o ke ola, a me nā waiwai hoʻopuka kikoʻī.