Etelcalcetide Hydrochloride

Etelcalcetide Hydrochloride API
ʻO ka Etelcalcetide Hydrochloride kahi moʻolelo synthetic peptide calcimimetic i hoʻomohala ʻia no ka mālama ʻana i ka hyperparathyroidism kiʻekiʻe (SHPT) i nā mea maʻi me ka maʻi maʻi maʻi maʻi (CKD) i ka hemodialysis. He pilikia maʻamau a koʻikoʻi ka SHPT i nā poʻe maʻi CKD, i hōʻike ʻia e nā pae kiʻekiʻe o ka parathyroid hormone (PTH), hoʻopilikia i ka metabolism calcium-phosphate, a piʻi aʻe ka pilikia o ka iwi a me ka maʻi cardiovascular.

Hōʻike ʻo Etelcalcetide i ka lua o ka hanauna calcimimetic, hoʻokele intravenously, a hāʻawi i nā mea maikaʻi ma mua o nā lāʻau lapaʻau waha mua e like me cinacalcet ma o ka hoʻomaikaʻi ʻana i ka hoʻokō ʻana a me ka hōʻemi ʻana i nā hopena ʻaoʻao o ka ʻōpū.

Mechanism of Action
Hana ʻo Etelcalcetide ma ka hoʻopaʻa ʻana a me ka hoʻōla ʻana i ka mea hoʻokipa calcium-sensing (CaSR) i loaʻa ma nā pūnaewele parathyroid gland. Hoʻohālikelike kēia i ka hopena physiological o ka calcium extracellular, e alakaʻi ana i:

Hoʻopau i ka huna ʻana o PTH

Hoʻemi i ka nui o ka calcium a me ka phosphate

Hoʻomaikaʻi i ke koena mineral a me ka metabolism iwi

Ma ke ʻano he peptide-based allosteric activator o CaSR, hōʻike ʻo Etelcalcetide i ka kikoʻī kiʻekiʻe a me ka hana hoʻomau ma hope o ka hoʻokele intravenous post-dialysis.

ʻImi ʻImi a me ka hopena lapaʻau
Ua loiloi nui ʻia ʻo Etelcalcetide ma ka pae 3 mau hoʻokolohua lapaʻau, me nā haʻawina EVOLVE, AMPLIFY, a me EQUIP. Loaʻa nā ʻike nui:

Hoʻemi nui a hoʻomau i nā pae PTH i nā maʻi CKD ma ka hemodialysis

Ka hoʻomalu maikaʻi ʻana i ka calcium serum a me ka phosphorus, e kōkua ana i ka hoʻomaikaʻi ʻana i ka homeostasis iwi-mineral

ʻOi aku ka maikaʻi o ka hiki ke hoʻohālikelike ʻia me nā calcimimetics waha (emi ʻole ka nausea a me ka luaʻi)

Hoʻomaikaʻi ʻia ka mālama ʻana o ka maʻi ma muli o ka hoʻokele IV ʻekolu pule i ka wā o ka dialysis

ʻO kēia mau pōmaikaʻi e hoʻolilo iā Etelcalcetide i kahi koho therapeutic koʻikoʻi no nā nephrologists e mālama ana i ka SHPT i nā heluna dialysis.

Ka maikaʻi a me ka hana ʻana
ʻO kā mākou Etelcalcetide Hydrochloride API:

Hoʻopili ʻia ma o ka solid-phase peptide synthesis (SPPS) me ka maʻemaʻe kiʻekiʻe

Hoʻohālikelike i nā kikoʻī o ka lāʻau lapaʻau, kūpono no nā ʻano hana injectable

Hōʻike i nā haʻahaʻa haʻahaʻa o nā koena solvents, haumia, a me nā endotoxins

Hiki ke hoʻonui ʻia no ka hoʻokumu ʻana i ka hui nui me ka GMP