Boc-His(Trt)-Aib-Gln(Trt)-Gly-OH

Boc-His(Trt)-Aib-Gln(Trt)-Gly-OH

Noi noiʻi:
Hoʻohana ʻia kēia tetrapeptide pale i ka peptide synthesis a me nā haʻawina conformational. ʻO ka hoʻohui ʻana o Aib (α-aminoisobutyric acid) hiki i nā mea noiʻi ke noiʻi i nā ʻano helical a me nā ʻano pelu i nā peptides pōkole. ʻO nā pūʻulu hana i pale ʻia (Boc, Trt) e hōʻoia i ka paʻa a me ke koho ʻana i ka wā solid-phase peptide synthesis, e lilo ia i kumu hoʻohālike koʻikoʻi no ke aʻo ʻana i nā dynamics iwi kuamoʻo peptide a me nā pilina ʻaoʻao-chain.

Hana:
Hana ʻo Boc-His(Trt)-Aib-Gln(Trt)-Gly-OH ma ke ʻano he kumu hoʻohālike no ka ʻimi ʻana i ka paʻa peptide a me nā kumu hoʻolālā. Hāʻawi ʻo Aib i ka helical stabilization, aʻo ka histidine a me nā koena glutamine e hāʻawi i nā pūnaewele pili pono, pono i ka hoʻolālā ʻana i nā peptides bioactive a i ʻole ka mimicking i nā ʻāpana protein. Hiki iā ia ke lilo i precursor no nā peptides hana i ka hoʻomohala ʻana i ka lāʻau lapaʻau a i ʻole nā ​​​​hōʻike biochemical.