Nā huahana
-
Ste-γ-Glu-AEEA-AEEA-OSU
ʻO Ste-γ-Glu-AEEA-AEEA-OSU kahi mole linker lipidated synthetic i hoʻolālā ʻia no ka hāʻawi ʻana i ka lāʻau lapaʻau a me nā conjugates antibody-drug (ADCs). He huelo stearoyl (Ste) hydrophobic, he γ-glutamyl motif huli ana, AEEA spacers no ka maʻalahi, a me kahi hui OSu (NHS ester) no ka hoʻohui maikaʻi ʻana.
-
Fmoc-Ile-αMeLeu-Leu-OH
ʻO Fmoc-Ile-αMeLeu-Leu-OH kahi poloka hale tripeptide pale synthetic e hōʻike ana i ka leucine α-methylated, i hoʻohana mau ʻia i ka hoʻolālā lāʻau peptide e hoʻomaikaʻi i ke kūpaʻa metabolic a me ka koho koho.
-
Dodecyl Phosphocholine (DPC)
ʻO Dodecyl Phosphocholine (DPC) kahi mea hoʻomaʻemaʻe zwitterionic synthetic i hoʻohana nui ʻia i ka noiʻi protein membrane a me ka biology structural, ʻoi loa i ka NMR spectroscopy a me crystallography.
-
N-Acetylneuraminic Acid(Neu5Ac Sialic Acid)
ʻO ka N-Acetylneuraminic Acid (Neu5Ac), i ʻike mau ʻia ʻo ialic acid, he monosaccharide kūlohelohe i komo i loko o nā hana koʻikoʻi a me nā hana pale. He kuleana koʻikoʻi ia i ka hōʻailona cell, pale pathogen, a me ka ulu ʻana o ka lolo.
-
Ergothioneine
ʻO Ergothioneine kahi antioxidant i loaʻa maoli i ka amino acid, i aʻo ʻia no kāna mau cytoprotective ikaika a me nā waiwai anti-kahiko. Hoʻopili ʻia ia e nā haʻiki a me ka bacteria a hōʻiliʻili i loko o nā ʻiʻo i ʻike ʻia i ke koʻikoʻi oxidative.
-
NMN
Hōʻike nā haʻawina preclinical a me nā kānaka mua i ka NMN e hoʻoikaika i ka lōʻihi o ke ola, ka hoʻomanawanui kino, a me ka hana naʻau.
Nā hiʻohiʻona API:
Maʻemaʻe kiʻekiʻe ≥99%
ʻO ka lāʻau lapaʻau, kūpono no ka waha a i ʻole ka injectable formulations
Hana ʻia ma lalo o nā kūlana GMP-like
He kūpono ka NMN API no ka hoʻohana ʻana i nā mea hoʻohui anti-aging, metabolic therapy, a me ka noiʻi lōʻihi.
-
Glucagon
ʻO Glucagon kahi hormone peptide kūlohelohe i hoʻohana ʻia ma ke ʻano he lāʻau ulia pōpilikia no ka hypoglycemia koʻikoʻi a aʻo ʻia no kāna kuleana i ka hoʻoponopono metabolic, pohō kaumaha, a me nā diagnostics digestive.
-
Motixafortide
ʻO Motixafortide kahi peptide antagonist synthetic CXCR4 i hoʻomohala ʻia e hoʻoneʻe i nā cell hematopoietic stem (HSCs) no ka hoʻololi autologous a ke aʻo ʻia nei hoʻi i ka oncology a me ka immunotherapy.
-
ʻO Glepaglutide
ʻO Glepaglutide kahi analog GLP-2 lōʻihi i hoʻomohala ʻia no ka mālama ʻana i ka maʻi pōkole pōkole (SBS). Hoʻonui ia i ka absorption intestinal a me ka ulu ʻana, kōkua i nā mea maʻi e hōʻemi i ka hilinaʻi ʻana i ka meaʻai makua.
-
Elamipretide
ʻO ka Elamipretide kahi tetrapeptide i manaʻo ʻia i ka mitochondria i hoʻomohala ʻia e mālama i nā maʻi i hoʻokumu ʻia e ka mitochondrial dysfunction, me ka myopathy mitochondrial mua, Barth syndrome, a me ka pau ʻole o ka naʻau.
-
Donidalorsen
ʻO Donidalorsen API kahi antisense oligonucleotide (ASO) ma lalo o ka hoʻokolokolo ʻana no ka mālama ʻana i ka angioedema hereditary (HAE) a me nā kūlana inflammatory pili. Ua aʻo ʻia i loko o ka pōʻaiapili o nā lāʻau lapaʻau i hoʻopaʻa ʻia i ka RNA, me ka manaʻo e hōʻemi i ka hōʻike ʻana oplasma prekallikrein(KLKB1 mRNA). Hoʻohana ka poʻe noiʻi iā Donidalorsen e ʻimi i nā mīkini silencing gene, pharmacokinetics hilinaʻi dose, a me ka hoʻomalu lōʻihi o ka ʻāʻī ʻana o bradykinin.
-
Fitusiran
ʻO Fitusiran API kahi RNA interfering liʻiliʻi liʻiliʻi (siRNA) i noiʻi nui ʻia ma ke kahua o ka hemophilia a me nā maʻi coagulation. Huli ia i kaantithrombin (AT a i ʻole SERPINC1)gene i loko o ke ake e ho'ēmi i ka hana antithrombin. Hoʻohana ka poʻe noiʻi iā Fitusiran e ʻimi i nā hana RNA interference (RNAi), silencing gene kikoʻī kikoʻī o ka ate, a me nā hoʻolālā therapeutic novel no ka hoʻoponopono hou ʻana i ka coagulation i nā maʻi hemophilia A a me B, me ka ʻole a i ʻole nā mea hoʻopaneʻe.