He aha ka Mounjaro (Tirzepatide)?

He lāʻau lapaʻau ʻo Mounjaro (Tirzepatide) no ka pohō kaumaha a me ka mālama ʻana i loaʻa i ka tirzepatide ikaika. ʻO Tirzepatide kahi mea ʻelua GIP a me GLP-1 receptor agonist. Loaʻa nā mea loaʻa ʻelua i loko o ka pancreatic alpha a me nā beta endocrine cell, naʻau, nā kīʻaha koko, nā cell immune (leukocytes), nā ʻōpū a me nā puʻupaʻa. Loaʻa nā mea loaʻa GIP i nā adipocytes.
Eia kekahi, hōʻike ʻia nā mea loaʻa GIP a me GLP-1 i nā ʻāpana lolo i mea nui no ka hoʻoponopono ʻana i ka makemake. Koho loa ʻo Tirzepatide no nā mea hoʻokipa GIP a me GLP-1 kanaka. He kiʻekiʻe ko Tirzepatide no nā mea loaʻa GIP a me GLP-1. ʻO ka hana o tirzepatide ma nā mea loaʻa GIP ua like ia me ka hormone GIP maoli. ʻOi aku ka haʻahaʻa o ka hana o tirzepatide ma GLP-1 ma mua o ka hormone GLP-1 maoli.
Hana ʻo Mounjaro (Tirzepatide) ma ka hana ʻana i nā mea loaʻa i loko o ka lolo e hoʻomalu i ka ʻai, e hoʻomāʻona iā ʻoe, emi ʻole ka pōloli, a emi ʻole ka makemake i ka meaʻai. E kōkua kēia iā ʻoe e ʻai liʻiliʻi a lilo i ke kaumaha.
Pono e hoʻohana ʻia ʻo Mounjaro me kahi hoʻolālā meaʻai hoʻemi-calorie a hoʻonui i ka hana kino.

Nā Koina Hoʻokomo

Hōʻike ʻia ʻo Mounjaro (Tirzepatide) no ka mālama ʻana i ke kaumaha, me ka hoʻemi ʻana a me ka mālama ʻana, ma ke ʻano he mea hoʻohui i ka meaʻai hoʻemi-calorie a me ka hoʻonui ʻana i ka hana kino i nā pākeke me kahi helu helu kino kino mua (BMI) o:
≥ 30 kg/m2 (obese), a i ʻole
≥ 27 kg/m2 a i lalo o 30 kg/m2 (kaumaha) me hoʻokahi maʻi pili i ke kaumaha e like me ka dysglycemia (prediabetes a i ʻole type 2 diabetes), hypertension, dyslipidemia, a i ʻole ka apnea moe obstructive Ka ʻae ʻana i ka mālama ʻana a me ka mālama ʻana i ka meaʻai kūpono.
makahiki 18-75 makahiki
Inā ʻaʻole e nalowale ka mea maʻi i ka liʻiliʻi o 5% o ko lākou kaumaha kino mua ma hope o 6 mau mahina o ka mālama ʻana, pono e hoʻoholo i ka hoʻomau ʻana i ka mālama ʻana, me ka noʻonoʻo ʻana i ka pōmaikaʻi/pilikia o ka mea maʻi.

Papa kuhikuhi dosing

ʻO ka hoʻomaka ʻana o ka tirzepatide he 2.5 mg i hoʻokahi pule. Ma hope o 4 mau pule, pono e hoʻonui ʻia ka nui i ka 5 mg i hoʻokahi pule. Inā pono, hiki ke hoʻonui ʻia ka nui e 2.5 mg no ka liʻiliʻi o 4 mau pule ma luna o ka nui o kēia manawa.
ʻO ka nui o ka mālama mālama ʻana he 5, 10, a me 15 mg.
ʻO ka nui loa he 15 mg i hoʻokahi pule.

ʻO ke ʻano dosing

Hiki ke lawelawe ʻia ʻo Mounjaro (Tirzepatide) i hoʻokahi pule i kēlā me kēia manawa o ka lā, me ka ʻai ʻole a i ʻole.
Pono e hoʻopili ʻia ma lalo o ka ʻōpū, ka ʻūhā, a i ʻole ka lima o luna. Hiki ke hoʻololi ʻia ka wahi injection. ʻAʻole pono e hoʻokomo ʻia i loko o ka intravenously a i ʻole intramuscularly.
Inā pono, hiki ke hoʻololi ʻia ka lā dosing pule e like me ka lōʻihi o ka manawa ma waena o nā doses ma kahi o 3 mau lā (> 72 mau hola). Ke koho ʻia kahi lā dosing hou, pono e hoʻomau ka dosing i hoʻokahi pule i kēlā me kēia pule.
Pono e aʻo ʻia nā mea maʻi e heluhelu i nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana i loko o ka ʻeke e hoʻokomo pono ma mua o ka lawe ʻana i ka lāʻau lapaʻau.