Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA-AEEA]-OH

Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA-AEEA]-OH

ʻO Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA-AEEA]-OH he mea hoʻohana ʻia ka amino acid building block i hoʻolālā ʻia no ka hāʻawi ʻana i ka lāʻau lapaʻau a me ka bioconjugation. Hōʻike ia i kahi moiety Eic (eicosanoid) no ka pilina lipid, γ-Glu no ka huli ʻana, a me nā spacers AEEA no ka maʻalahi.

 
Noiʻi a me nā noi:

Hoʻohana ʻia i ka synthesis prodrug, hoʻomohala ADC, a me ka hoʻolālā nanocarrier

Hoʻonui i ka huli ʻana o ka membrane, solubility, a me ka pono conjugation

He kūpono no SPPS i ka noiʻi peptide-drug conjugate kiʻekiʻe

Nā hiʻohiʻona huahana (Gentolex Group):

Mālama ʻia ka Fmoc, maʻemaʻe kiʻekiʻe (≥99%)

Loaʻa i nā pūʻulu OtBu hiki ke hoʻokaʻawale ʻia no ka synthesis hoʻomalu

He kūpono ʻo Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA-AEEA]-OH no nā ʻōnaehana hoʻopuka pololei a me ka hoʻolālā peptide hana.