Fitusiran

Fitusiran (API)

Noi noiʻi:
ʻO Fitusiran API kahi RNA interfering liʻiliʻi liʻiliʻi (siRNA) i noiʻi nui ʻia ma ke kahua o ka hemophilia a me nā maʻi coagulation. Huli ia i kaantithrombin (AT a i ʻole SERPINC1)gene i loko o ke ake e ho'ēmi i ka hana antithrombin. Hoʻohana ka poʻe noiʻi iā Fitusiran e ʻimi i nā hana RNA interference (RNAi), silencing gene kikoʻī kikoʻī o ka ate, a me nā hoʻolālā therapeutic novel no ka hoʻoponopono hou ʻana i ka coagulation i nā maʻi hemophilia A a me B, me ka ʻole a i ʻole nā ​​mea hoʻopaneʻe.

Hana:
Hana ʻo Fitusiran ma ka hoʻopaʻa ʻana i ka hōʻike o ka antithrombin, kahi anticoagulant kūlohelohe, a laila e hoʻonui ai i ka thrombin generation a me ka hoʻoikaika ʻana i ka hoʻokumu ʻana o ka clot. Hāʻawi kēia mīkini i kahi ala lapaʻau prophylactic e hōʻemi i nā ʻāpana koko i nā maʻi hemophilia. Ma ke ʻano he API, lawelawe ʻo Fitusiran ma ke ʻano he mea hana i nā lāʻau lapaʻau subcutaneous lōʻihi e kuhikuhi ana i ka hoʻomaikaʻi ʻana i ka maikaʻi o ke ola a me ka hōʻemi ʻana i ke kaumaha o ka mālama ʻana i nā maʻi koko.