AEEA-AEEA

AEEA-AEEA (Aminoethoxyethoxyacetate dimer)

Noi noiʻi:
ʻO AEEA-AEEA he hydrophilic, maʻalahi spacer i hoʻohana mau ʻia i ka peptide a me ka noiʻi conjugation lāʻau. Aia i loko o ʻelua mau ʻāpana ethylene glycol, pono ia no ke aʻo ʻana i nā hopena o ka lōʻihi o ka loulou a me ka maʻalahi i ka pilina molekala, solubility, a me ka hana olaola. Hoʻohana pinepine ka poʻe noiʻi i nā ʻāpana AEEA e loiloi i ka hopena o nā spacers i ka hana o nā antibody-drug conjugates (ADCs), peptide-drug conjugates, a me nā bioconjugates ʻē aʻe.

Hana:
Hana ʻo AEEA-AEEA ma ke ʻano he mea hoʻohui biocompatible e hoʻonui ai i ka solubility, e hoʻemi i ka ʻae ʻana i ka steric, a hoʻomaikaʻi i ka molecular flexibility. Kōkua ia i ka hoʻokaʻawale ʻana i nā kikowaena hana i loko o kahi mole, e like me ka huli ʻana i nā ligands a me nā uku, e ʻae ai i ka hoʻopaʻa ʻana a me ka hana ʻoi aku ka maikaʻi. ʻO kona ʻano non-immunogenic a me ka hydrophilic e hāʻawi pū i ka hoʻomaikaʻi ʻana i nā profile pharmacokinetic i nā noi therapeutic.